CEFAC

Centro de Estudos Farmacêuticos e Cosméticos


2023



GC/MS and 2D NMR-based approach to evaluate the chemical profile of hydroalcoholic extract from Agaricus blazei Murill and its anti-inflammatory effect on human neutrophils.


Evaluation of the skin whitening and antioxidant activity of Myracrodum urundeuva extract (aroeira-do-sertão).


Anacardic Acid Mixture: Utilization of a Byproduct for the Sustainable Development of a Potential Antichagasic Agent Against Trypanosoma cruzi.


Physicochemical Characterization and Biological Evaluation of Agaricus subrufescens Polysaccharides in Human Blood Cells.

 

Leishmanicidal and healing effects of 3β,6β,16β-trihydroxy lup-20 (29)-ene isolated from Combretum leprosum on Leishmania braziliensis infection in vitro and in vivo.


Stainless steel and titanium alloys coated with sulfated chitosan to improve hemocompatibility properties


Epiisopiloturine, an Alkaloid from Pilocarpus microphyllus, Attenuates LPS-Induced Neuroinflammation by Interfering in the TLR4/NF-κB-MAPK Signaling Pathway in Microglial Cells


Agaricus blazei Murill extract-loaded in alginate/poly(vinyl alcohol) films prepared by Ca 2+ cross-linking for wound healing applications

 




2022

 

Anxiolytic Effect of Carvedilol in Chronic Unpredictable Stress Model


Sorbitan Monolaurate-Containing Liposomes Enhance Skin Cancer Cell Cytotoxicity and in Association with Microneedling Increase the Skin Penetration of 5-Fluorouracil


Antineuroinflammatory Effect of Amburana cearensis and Its Molecules Coumarin and Amburoside A by Inhibiting the MAPK Signaling Pathway in LPS-Activated BV-2 Microglial Cells


Effects of polysaccharides isolated from mushrooms (Lentinus edodes Berk or Agaricus blazei Murill) on the gelation of Pluronic® F127






2021

 

Seroprevalence and risk factors of Chagas disease in a rural population of the Quixeré municipality, Ceará, Brazil. 


Polysaccharides and extracts from Agaricus brasiliensis Murill - A comprehensive review.


Untargeted GC/MS-based approach for identification of anti-inflammatory alkaloids from Hippeastrum elegans (Amaryllidaceae) using a human neutrophil model.


Anti-diarrheal therapeutic potential of diminazene aceturate stimulation of the ACE II/Ang-(1-7)/Mas receptor axis in mice: A trial study.


A novel amino phosphonate-coated magnetic nanoparticle as MRI contrast agent.A novel amino phosphonate-coated magnetic nanoparticle as MRI contrast agent.


Cashew apple pectin as a carrier matrix for mangiferin: Physicochemical characterization, in vitro release and biological evaluation in human neutrophils.   

 

 



2020

 

In vitro toxicological characterisation of the antifungal compound soybean toxin (SBTX).

 

Medicinal Plants Containing Coumarin or Essential Oils from the Brazilian Biome May be New Option for Treating Leishmaniasis?

 

Vitamin D (VD3) antioxidative and anti-inflammatory activities: Peripheral and central effects.

 

Evaluation of oxidative stability of soybean biodiesel using ethanolic and chloroform extracts of Platymiscium floribundum as antioxidant.

 

Chitosan and Agaricus brasiliensis Polysaccharides Films: A Preliminary Study.

 

Binary Micelles (E45S8/F127) For Quercetin and Griseofulvin solubilisation.

 

Disorders on cardiovascular parameters in rats and in human blood cells caused by Lachesis acrochorda snake venom.

 

Spondias mombin: quality control and anti-inflammatory activity in human neutrophils.

 

Uncaria tomentosa reduces osteoclastic bone loss in vivo.

 

 

 

 

2019

 

Alendronate-induced gastric damage in normoglycemic and hyperglycemic rats is reversed by metformin

 

The Wound Healing Property of N -Methyl-(2 S ,4 R )- trans -4-Hydroxy-L-Proline from Sideroxylon obtusifolium is Related to its Anti-Inflammatory and Antioxidant Actions

 

Chemical Composition and Anti-Inflammatory Activity of the Decoction from Leaves of a Cultivated Specimen of Myracrodruon urundeuva. 

 

Gastrointestinal effects of standardized Brazilian phytomedicine (Arthur de Carvalho Drops®) containing Matricaria recutita, Gentiana lutea and Foeniculum vulgare.

 

Imidazole alkaloids inhibit the pro-inflammatory mechanisms of human neutrophil and exhibit anti-inflammatory properties in vivo

 

α-Glucosidase inhibitory activity of mangiferin-loaded F127/PEG micellar system.

 

 

 

 

2018

 

Aspidosperma pyrifolium Mart: neuroprotective, antioxidant and anti-inflammatory effects in a Parkinson's disease model in rats

 

Ethanolic Extract of Erythrina Velutina Willd. Pretreatment Attenuates Schizophrenia-Like Behaviors and Oxidative Parameters in Experimental Animal Models.

 

Eugenol as a promising molecule for the treatment of dermatitis: antioxidant and anti-inflammatory activities and its nanoformulation.

 

Flavonoids: biological activities and therapeutic potential.

 

Hemocompatibility of 2- N -3,6- O -sulfated chitosan films.

 

 

 

2017

 

Effects Of Standard Ethanolic Extract From Erythrina Velutina In Acute Cerebral Ischemia In Mice.

 

Inhibitory Effects Of A Standardized Extract Of Justicia Pectoralis In An Experimental Rat Model Of Airway Hyper-Responsiveness

 

Justicia Pectoralis, A Coumarin Medicinal Plant Have Potential For The Development Of Antiasthmatic Drugs

 

Neuroprotective Activities Of Spirulina Platensis In The 6-OHDA Model Of Parkinson?S Disease Are Related To Its Anti-Inflammatory Effects

 

Preliminary Evaluation Of Novel Triglyceride-Based Nanocomposites For Biomedical Applications

 

The Anti-Inflammatory Effects Of N-Methyl-(2S,4R)-Trans-4-Hydroxy-L-Proline From Syderoxylon Obtusifolium Are Related To Its Inhibition Of TNF-Alpha And Inflammatory Enzymes. Phytomedicine (Stuttgart)

 

Validation Of A High Performance Liquid Chromatography Method To Quantify Thymol In Nanocapsules Of Bioactive Essential Oil From Lippia Sidoides

 

 

 

2016

 

Evidence for protective effect of lipoic acid and desvenlafaxine on oxidative stress in a model depression in mice.

 

Dry Extract of Matricaria Recutita L. (Chamomile) Prevents Ligature-Induced Alveolar Bone Resorption in Rats via Inhibition of TNF‐α and IL-1β.

 

First Isolation and Antinociceptive Activity of a Lipid Transfer Protein from Noni (Morinda citrifolia) Seeds.

 

antioxidant and neurotrophic properties of the standardized extract of Cocos nucifera husk fiber in mice.

 

Caryocar coriaceum Wittm. (Pequi) fixed oil presents hypolipemic and anti-inflammatory effects in vivo and in vitro.

 

Antinociceptive and Anti-Inflammatory Effects of Ketamine and the Relationship to its Antidepressant Action and GSK3 Inhibition.

 

Involvement of monoaminergic systems in anxiolytic and antidepressive activities of the standardized extract of Cocos nucifera L..

 

Pharmacognostical analysis and protective effect of standardized extract and rizonic acid from Erythrina velutina against 6-hydroxydopamine-induced neurotoxicity in SH-SY5Y cells.

 

Polysaccharides from Caesalpinia ferrea seeds - Chemical characterization and anti-diabetic effects in Wistar rats. Food Hydrocolloids.

 

Phytochemical analysis of the decoction from leaves of cultivated specimens of Myracrodruon urundeuva (-aroeira-do-sertão-).

 

 

 

2015

 

Red propolis ameliorates ischemic-reperfusion acute kidney injury. Phytomedicine (Stuttgart).

 

Valproic Acid Neuroprotection in the 6-OHDA Model of Parkinson’s Disease Is Possibly Related to Its Anti-Inflammatory and HDAC Inhibitory Properties.

 

Neuroprotective Properties of the Standardized Extract from (Green Tea) and Its Main Bioactive Components, Epicatechin and Epigallocatechin Gallate, in the 6-OHDA Model of Parkinson's Disease.

 

Binary Micellar Solutions of Poly(Ethylene Oxide)-Poly(Styrene Oxide) Copolymers with Pluronic® P123: Drug Solubilisation and Cytotoxicity Studies.

 

Pentoxifylline Neuroprotective Effects Are Possibly Related to Its Anti-Inflammatory and TNF-Alpha Inhibitory Properties, in the 6-OHDA Model of Parkinson’s Disease.

 

The Effect of a Selective Inhibitor of Phosphodiesterase-9 on Oxidative Stress, Inflammation and Cytotoxicity in Neutrophils from Patients with Sickle Cell Anaemia.